From a hunting standpoint, early-stage CWD bucks aren't visually different from healthy bucks. The disease becomes a concern at the post-harvest stage when meat is being handled and prepared for consumption.
In high-prevalence CWD zones, mature buck age structure can shift over time as more bucks die in middle age before reaching trophy class. State wildlife agencies track this through age-at-harvest data. See disease risk pages for prevalence rates.